Burkitt lymphomaB-cell lymphoma; High-grade B-cell lymphoma; Small noncleaved cell lymphoma
Burkitt lymphoma (BL) is a very fast growing form of non-Hodgkin lymphoma.
BL was first discovered in children in certain parts of Africa. It also occurs in the United States.
People with HIV/AIDS have an increased risk for this condition. BL is most often seen in males.
BL may first be noticed as a swelling of the lymph nodes (glands) in the head and neck. These swollen lymph nodes are often painless, but can grow very rapidly.
In the types commonly seen in the United States, the cancer often starts in the belly area (abdomen). The disease can also start in the ovaries, testes, brain, kidneys, liver, and spinal fluid.
Other general symptoms may include:
- Night sweats
- Unexplained weight loss
Exams and Tests
The health care provider will perform a physical exam. Tests that may be done include:
- Bone marrow biopsy
- Chest x-ray
- CT scan of the chest, abdomen, and pelvis
- Complete blood count (CBC)
- Examination of the spinal fluid
- Lymph node biopsy
- PET scan
Chemotherapy is used to treat this type of cancer. If the cancer does not respond to chemotherapy alone, a bone marrow transplant may be done.
More than one half of people with BL can be cured with intensive chemotherapy. The cure rate may be lower if the cancer spreads to the bone marrow or spinal fluid. The outlook is poor if the cancer comes back after a remission or does not go into remission as a result of the first cycle of chemotherapy.
Possible complications of BL include:
- Complications of treatment
- Spread of the cancer
When to Contact a Medical Professional
Call your provider if you have symptoms of BL.
Gallagher CJ, Smith M, Shamash J. Malignant disease. In: Kumar P, Clark M, eds. Kumar and Clark's Clinical Medicine. 9th ed. Philadelphia, PA: Elsevier; 2017:chap 17.
Gascoyne RD, Siebert R, Connors JM, Kluin PM. Burkitt's lymphoma and its mimics. In: Jaffe ES, Arber DA, Campo E, Harris NL, Quintanilla-Martinez L, eds. Hematopathology. 2nd ed. Philadelphia, PA: Elsevier; 2017:chap 24.
National Cancer Institute website. Adult non-Hodgkin lymphoma treatment (PDQ) – health professional version. www.cancer.gov/types/lymphoma/hp/adult-nhl-treatment-pdq#section/all. Updated April 20, 2018. Accessed May 7, 2018.
Review Date: 4/11/2018
Reviewed By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.