Neuropathy; Isolated mononeuritis

Mononeuropathy is damage to a single nerve, which results in loss of movement, sensation, or other function of that nerve.


Mononeuropathy is a type of damage to a nerve outside the brain and spinal cord (peripheral neuropathy).

Mononeuropathy is most often caused by injury. Diseases affecting the entire body (systemic disorders) can also cause isolated nerve damage.

Long-term pressure on a nerve due to swelling or injury can result in mononeuropathy. The covering of the nerve (myelin sheath) or part of the nerve cell (the axon) may be damaged. This damage slows or prevents signals from traveling through the damaged nerves.

Mononeuropathy may involve any part of the body. Some common forms of mononeuropathy include:

  • Axillary nerve dysfunction (loss of movement or sensation in the shoulder)
  • Common peroneal nerve dysfunction (loss of movement or sensation in the foot and leg)
  • Carpal tunnel syndrome (median nerve dysfunction -- including numbness, tingling, weakness, or muscle damage in the hand and fingers)
  • Cranial mononeuropathy III, IV, compression or diabetic type
  • Cranial mononeuropathy VI (double vision)
  • Cranial mononeuropathy VII (facial paralysis)
  • Femoral nerve dysfunction (loss of movement or sensation in part of the leg)
  • Radial nerve dysfunction (problems with movement in the arm and wrist and with sensation in the back of the arm or hand)
  • Sciatic nerve dysfunction (problem with the muscles of the back of the knee and lower leg, and sensation to the back of the thigh, part of the lower leg, and sole of the foot)
  • Ulnar nerve dysfunction (cubital tunnel syndrome -- including numbness, tingling, weakness of outer and underside of arm, palm, ring and little fingers)


Symptoms depend on the specific nerve affected, and may include:

Exams and Tests

The health care provider will perform a physical exam and focus on the affected area. A detailed medical history is needed to determine the possible cause of the disorder.

Tests that may be done include:

  • Electromyogram (EMG) to check the electrical activity in the muscles
  • Nerve conduction tests (NCV) to check the speed of electrical activity in the nerves
  • Nerve ultrasound to view the nerves
  • X-ray, MRI or CT scan to get an overall view of the affected area
  • Blood tests
  • Nerve biopsy (in case of mononeuropathy due to vasculitis)
  • CSF examination
  • Skin biopsy


The goal of treatment is to allow you to use the affected body part as much as possible.

Some medical conditions make nerves more prone to injury. For example, high blood pressure and diabetes can injure an artery, which can often affect a single nerve. So, the underlying condition should be treated.

Treatment options may include any of the following:

  • Over the counter painkillers, such as anti-inflammatory medicines for mild pain
  • Antidepressants, anticonvulsants, and similar medicines for chronic pain
  • Injections of steroid medicines to reduce swelling and pressure on the nerve
  • Surgery to relieve pressure on the nerve
  • Physical therapy exercises to maintain muscle strength
  • Braces, splints, or other devices to help with movement
  • Transcutaneous electrical nerve stimulation (TENS) to improve nerve pain associated with diabetes

Support Groups

The following groups can provide more information and resources:

Outlook (Prognosis)

Mononeuropathy may be disabling and painful. If the cause of the nerve dysfunction can be found and successfully treated, a full recovery is possible in some cases.

Nerve pain may be uncomfortable and last for a long time.

Possible Complications

Complications may include:

  • Deformity, loss of tissue mass
  • Medicine side effects
  • Repeated or unnoticed injury to the affected area due to lack of sensation


Avoiding pressure or traumatic injury may prevent many forms of mononeuropathy. Treating conditions such as high blood pressure or diabetes also decreases the risk of developing the condition.


National Institute of Neurological Disorders and Stroke website. Peripheral neuropathy fact sheet. Updated April 24, 2018. Accessed August 1, 2018.

Shy ME. Peripheral neuropathies. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 420.

Snow DC, Bunney EB. Peripheral nerve disorders. In: Walls RM, Hockberger RS, Gausche-Hill M, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice. 9th ed. Philadelphia, PA: Elsevier; 2018:chap 97.


    • Central nervous system and peripheral nervous system

      Central nervous system and peripheral nervous system


      • Central nervous system and peripheral nervous system

        Central nervous system and peripheral nervous system



      Review Date: 4/30/2018

      Reviewed By: Amit M. Shelat, DO, FACP, Attending Neurologist and Assistant Professor of Clinical Neurology, SUNY Stony Brook, School of Medicine, Stony Brook, NY. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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